clm-8mh25qv6x9

ILA (Infralimbic area) functionally connects to CEA (central amygdaloid nucleus)

Species: Rat
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Blue-light stimulation of ChR2-expressing IL terminals in amygdala slices evoked EPSCs in CeLC neurons that disappeared with TTX, were restored by 4-AP and abolished by CNQX, indicating a monosynaptic glutamatergic input; the same stimulation also produced longer-latency, CNQX- and picrotoxin-sensitive IPSCs, consistent with disynaptic feed-forward inhibition, and in vivo photostimulation of these terminals lowered c-Fos counts in CeLC.
Measurements: conduction delay: 0 ms, n = 12
Source: Projections from infralimbic medial prefrontal cortex glutamatergic outputs to amygdala mediates opioid induced hyperalgesia in male rats
Molecular Pain, 2024
DOI 10.1177/17448069241226960 · PubMed 38172075 · PMC10851759, Fig. 3(c)-(e), Fig. 4(b)-(d), Fig. 5(f), (g)
Licence: CC-BY-NC-4.0
Named in the paper: “IL” and “CeLC”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) disagrees, 2026-10-09
“The functional IL→CeLC excitatory connection is supported, but the attached number (conduction delay 0.0 ms) is not a value the paper reports for this connection.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.