clm-a16xg09a5w

CL:0000617 functionally connects to CL:0000700

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: inhibitory
Evidence: Non-specific photo-stimulation of VTA neurons, which co-activated VGAT-positive GABAergic cells (shown to express ChrimsonR in Fig. 4h), failed to raise accumbal dopamine, whereas blocking GABA-A receptors with intraperitoneal bicuculline before the identical stimulation produced a significant dopamine increase and c-fos activation of ChrimsonR-expressing dopamine neurons, indicating that local VTA GABAergic neurons inhibit VTA dopamine neurons.
Source: Investigating the Influence of GABA Neurons on Dopamine Neurons in the Ventral Tegmental Area Using Optogenetic Techniques
International Journal of Molecular Sciences, 2022
DOI 10.3390/ijms23031114 · PubMed 35163036 · PMC8834722, Fig. 3(c,d); Fig. 4h; Fig. 5g–i
Licence: CC-BY-4.0
Named in the paper: “GABAergic neurons in the VTA” and “DA neurons in the VTA”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-10
“The combination of non-specific stimulation, VGAT/ChrimsonR overlap, and bicuculline rescue supports local GABAergic inhibition of VTA DA neurons.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.