clm-jgkwagd7ew

CEA corticotropin-releasing hormone-expressing neurons functionally connects to CP (Caudoputamen)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: inhibitory
Evidence: AAV-FLEX-Chrimson-tdTomato was injected into both CeA and BNST of CRF-Cre;ChAT-eGFP mice; light stimulation of the labelled fibres in dorsal striatum evoked short-latency synaptic currents in GFP+ cholinergic interneurons that were abolished by TTX, restored by TTX+4-AP (indicating monosynaptic transmission) and blocked by the GABA-A antagonist bicuculline.
Measurements: conduction delay: 6.5 ms, n = 8
Source: Alcohol attenuates CRF-induced excitatory effects from the extended amygdala to dorsostriatal cholinergic interneurons
eLife, 2026
DOI 10.7554/elife.107145 · PubMed 41870239 · PMC13008356, Fig. 3G–3J
Licence: CC-BY-4.0
Named in the paper: “CeA CRF+ neurons” and “dorsal striatal cholinergic interneurons (CINs)”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-10
“CeA CRF+ fibers (Chrimson) evoked short-latency bicuculline-sensitive currents in CINs, monosynaptic by TTX/4-AP.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.