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BLA (basal amygdaloid nucleus) functionally connects to PL (Prelimbic area)

Species: Rat
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Light stimulation of ChR2-expressing BLA terminals in PrL slices evoked excitatory currents in retrobead-labelled PAG-projecting neurons. These currents persisted in TTX/4-AP, consistent with monosynaptic input, and had an APV-sensitive NMDA component. The same stimulation also evoked feedforward inhibitory currents, which were reduced after adolescent ethanol exposure.
Source: Adolescent alcohol exposure promotes mechanical allodynia and alters synaptic function at inputs from the basolateral amygdala to the prelimbic cortex
eLife, 2025
DOI 10.7554/elife.101667 · PubMed 40338067 · PMC12061479, Figs. 5-7
Licence: CC-BY-4.0
Named in the paper: “basolateral amygdala (BLA)” and “PrLPAG neurons (PrL pyramidal neurons projecting to vlPAG)”
Made by: an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-10
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-10
“Optically stimulating BLA terminals evoked glutamatergic AMPA and NMDA currents that survived TTX/4-AP, plus feedforward IPSCs that AIE reduced (Figs. 5-7).”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.