BLA (basal amygdaloid nucleus) functionally connects to PL (Prelimbic area)

Light stimulation of ChR2-expressing BLA terminals in PrL slices evoked excitatory currents in retrobead-labelled PAG-projecting neurons. These currents persisted in TTX/4-AP, consistent with monosynaptic input, and had an APV-sensitive NMDA component. The same stimulation also evoked feedforward inhibitory currents, which were reduced after adolescent ethanol exposure.

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Optogenetic activation of BLA terminals evoked excitatory currents in mCherry-tagged PrL PV interneurons. The currents included monosynaptic AMPA and APV-sensitive NMDA components and asynchronous EPSCs recorded under TTX/4-AP, and they were reduced by adolescent ethanol exposure.

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