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LC (Locus ceruleus) projects to PL (Prelimbic area)

Species: Rat
Result: present
Method: retrograde tracer
Sign: modulatory
Evidence: Fluorescent dextran injected at the border of prelimbic and infralimbic cortex retrogradely labelled LC neurons, in numbers statistically indistinguishable from those labelled from CeA, and these cells were largely distinct from the CeA-projecting population (~7.6% double-labelled). A retrogradely transported noradrenergic-selective CAV2-PRS-Cre vector injected into mPFC likewise transduced LC neurons.
Source: Anatomically and functionally distinct locus coeruleus efferents mediate opposing effects on anxiety-like behavior
Neurobiology of Stress, 2020
DOI 10.1016/j.ynstr.2020.100284 · PubMed 33344735 · PMC7739179, Fig. 1E, 1G, 1I; Fig. 3B,D; Methods (Surgery)
Licence: CC-BY-4.0
Named in the paper: “locus coeruleus (LC)” and “medial prefrontal cortex (mPFC)”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.