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PL (Prelimbic area) projects to ACB (Nucleus accumbens)

All claims for this connection
Species
Mouse
Result
present
Method
retrograde tracer
Sign
unknown
Evidence
After bilateral injection of Alexa-conjugated CTB into the NAc lateral core and shell, retrogradely labelled cells were found in the PL (about 170 cells/mm2); roughly 90% of them (743/829) were immunopositive for glutamate, and about 2.7% were c-Fos positive after 1-h restraint.
Source

A Group of Descending Glutamatergic Neurons Activated by Stress in Corticolimbic Regions Project to the Nucleus Accumbens

Experimental Neurobiology, 2018

DOI 10.5607/en.2018.27.5.387 · PubMed 30429648 · PMC6221842, Fig. 1E; Fig. 2A-C; Fig. 3A-C
Named in the paper
“prelimbic cortex (PL)” and “nucleus accumbens (NAc)”
Made by
an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-10
Checked by

a second AI model (claude-opus-5-5) agrees, 2026-10-10

“The PL results show 167–175 CTB cells/mm2 after NAc core/shell injection, 89.8% (743/829) glutamatergic and 2.7% c-Fos positive after restraint.”

Status

proposed

Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.