Mouse
PL (Prelimbic area) projects to ACB (Nucleus accumbens)
3 claims from 3 sources: 3 found, 0 tested and absent, 0 ambiguous. Evidence: anterograde tracer, retrograde tracer. Strongest reported: strong.
The claims behind it
Retrograde AAV expressing Cre-GFP was injected into the nucleus accumbens with a Cre-dependent Gi-DREADD-mCherry vector in prelimbic cortex; co-labelled Cre+/mCherry+ neurons in PL demonstrate a prelimbic projection to the accumbens.
DOI 10.1038/s41467-022-32388-9 · PubMed 35970891 · PMC9378688, Fig. 5e (right panel); Methods, Table 2Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.
Retrograde CTB in the nucleus accumbens labelled prelimbic cortex neurons in addition to IL neurons, and retrobeads placed in the NAc allowed recordings from identified PL-NAc projection neurons.
DOI 10.1038/s41398-018-0106-x · PubMed 29507292 · PMC5838104, Fig. 1c–d; Fig. 3a,h–k; Results, 'Separate IL and PL projections to BLA and NAc'Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.
ChR2-eYFP expressed in prefrontal D1 neurons produced prominent labelled axons in the medial nucleus accumbens, both shell and core.
DOI 10.1038/nn.3625 · PubMed 24441680 · PMC3968853, Fig. 5a legend; Supplemental Fig. 7a,b; Results, 'Downstream targets of mPFC stimulation'Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.