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ORB (Orbital area) functionally connects to BLA glutamatergic principal neurons

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Blue-light activation of ChR2-expressing orbitofrontal axons in slices evoked excitatory postsynaptic currents in BLA pyramidal neurons; the responses disappeared with tetrodotoxin and returned with 4-aminopyridine, indicating a monosynaptic glutamatergic (AMPAR/NMDAR-mediated) input.
Source: Stress induces insertion of calcium-permeable AMPA receptors in the OFC–BLA synapse and modulates emotional behaviours in mice
Translational Psychiatry, 2020
DOI 10.1038/s41398-020-0837-3 · PubMed 32424318 · PMC7235080, Fig. 1c,d; Fig. 2f-k
Licence: CC-BY-4.0
Named in the paper: “OFC” and “BLA pyramidal neurons”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-09
“Light-evoked OFC EPSCs in BLA pyramidal neurons were abolished by TTX and rescued by 4-AP, showing a monosynaptic excitatory input with AMPAR/NMDAR components.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.