clm-q6qrn51949

LC (Locus ceruleus) projects to CEA (central amygdaloid nucleus)

Species: Rat
Result: present
Method: retrograde tracer
Sign: modulatory
Evidence: Fluorescent dextran injected into CeA retrogradely labelled neurons throughout the dorsoventral extent of LC, with a bias toward the dorsal part; in the same animals only about 7.6% of all labelled LC cells carried both the CeA and mPFC tracers, indicating largely separate populations. A retrogradely transported CAV2 vector with a noradrenergic-selective PRS promoter injected into CeA also transduced LC neurons, confirming the pathway arises from noradrenergic LC cells.
Source: Anatomically and functionally distinct locus coeruleus efferents mediate opposing effects on anxiety-like behavior
Neurobiology of Stress, 2020
DOI 10.1016/j.ynstr.2020.100284 · PubMed 33344735 · PMC7739179, Fig. 1E, 1G, 1H; Fig. 3A,C; Methods (Surgery)
Licence: CC-BY-4.0
Named in the paper: “locus coeruleus (LC)” and “central nucleus of the amygdala (CeA)”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.