clm-re8d1g14ev

PGRN (Paragigantocellular reticular nucleus) projects to LC (Locus ceruleus)

Species: Rat
Result: present
Method: retrograde tracer
Sign: unknown
Evidence: Iontophoretic Fluorogold injections into the LC core and dorsolateral peri-LC consistently labeled cell bodies in the PGi in every case. Some of these retrogradely labeled PGi cells were enkephalin-immunoreactive.
Source: Social Stress Engages Neurochemically-Distinct Afferents to the Rat Locus Coeruleus Depending on Coping Strategy
eneuro, 2015
DOI 10.1523/eneuro.0042-15.2015 · PubMed 26634226 · PMC4660134, Results, 'Repeated stress and retrograde labeling'; Fig. 1B; Fig. 2
Named in the paper: “nucleus paragigantocellularis (PGi)” and “locus coeruleus (LC)”
Made by: an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-09
“The Results and Fig. 1B report consistent PGi labeling from LC injections, and Fig. 2 shows enkephalin-positive retrogradely labeled PGi cells.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.