Social Stress Engages Neurochemically-Distinct Afferents to the Rat Locus Coeruleus Depending on Coping Strategy

CEA (central amygdaloid nucleus) UBERON:0002883 projects to LC (Locus ceruleus) UBERON:0002148 · Rat

Fluorogold placed in the LC and the dorsolateral peri-LC produced retrogradely labeled neurons in the central amygdalar nucleus in all animals examined.

Results, 'Repeated stress and retrograde labeling'; Fig. 1C

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.

Rat central amygdala corticotropin-releasing hormone-expressing neurons nt-sexhekqxaa projects to LC (Locus ceruleus) UBERON:0002148 · Rat

Some CNA neurons retrogradely labeled with Fluorogold from the LC were also CRF-immunoreactive. Triple-labeled cells (FG, CRF and c-fos) were identified in the CNA.

Results, 'Repeated social stress-induced activation of LC-projecting CRF neurons in the CNA'; Fig. 3

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PGRN (Paragigantocellular reticular nucleus) UBERON:0016635 projects to LC (Locus ceruleus) UBERON:0002148 · Rat

Iontophoretic Fluorogold injections into the LC core and dorsolateral peri-LC consistently labeled cell bodies in the PGi in every case. Some of these retrogradely labeled PGi cells were enkephalin-immunoreactive.

Results, 'Repeated stress and retrograde labeling'; Fig. 1B; Fig. 2

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.