clm-s62dnfwmjj

BLA glutamatergic principal neurons functionally connects to CEA (Central amygdalar nucleus)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Cre-dependent ChR2 was expressed in BLA excitatory neurons of CaMKII-Cre mice; blue-light stimulation of their terminals in the CeA elicited EPSCs in CeA neurons that were abolished by the AMPA receptor blocker DNQX, indicating a glutamatergic BLA-to-CeA input. These light-evoked EPSCs were suppressed by the DOR1 agonist DPDPE in normal and 4-h CFA mice but by neither DPDPE nor deltorphin II in 7-day CFA mice.
Source: Switching of delta opioid receptor subtypes in central amygdala microcircuits is associated with anxiety states in pain
Journal of Biological Chemistry, 2021
DOI 10.1016/j.jbc.2021.100277 · PubMed 33428940 · PMC7948800, Fig. 3, A–F
Licence: CC-BY-4.0
Named in the paper: “BLAGlu (CaMKII-Cre excitatory neurons of the BLA)” and “CeA”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-09
“Light-evoked, DNQX-sensitive EPSCs in CeA neurons after stimulating terminals from BLA CaMKII-Cre neurons support an excitatory optogenetic connection, and the DOR effects match Fig. 3.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.