clm-srg51y2426

HIP (Hippocampal region) functionally connects to LA (Lateral amygdalar nucleus)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: Photostimulating ChR2-expressing vHPC terminals evoked AMPAR- and NMDAR-mediated EPSCs in every recorded LA neuron. The responses were abolished by TTX and restored by 4-AP, which indicates monosynaptic input. Feedforward IPSCs were also evoked.
Source: Input associativity underlies fear memory renewal
National Science Review, 2021
DOI 10.1093/nsr/nwab004 · PubMed 34691732 · PMC8433092, Fig. 3A–H; Supplementary Fig. 7A–C; Fig. 5C–F
Licence: CC-BY-4.0
Named in the paper: “vHPC” and “LA”
Made by: an AI model reading the paper (claude-opus-5-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-09
“Every recorded LA cell showed vHPC oEPSCs that were TTX-sensitive and 4-AP-restored, with AMPAR and NMDAR components and feedforward oIPSCs.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.