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PB (Parabrachial nucleus) functionally connects to CEA (Central amygdalar nucleus)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: excitatory
Evidence: ChR2 expressed in PBN excitatory neurons of CaMKII-Cre mice allowed light stimulation of PBN terminals in the CeA, which reliably evoked EPSCs in CeA neurons that were blocked by DNQX. The DOR1 agonist DPDPE reduced these EPSCs in normal and 4-h CFA mice, whereas in 7-day CFA mice the DOR2 agonist deltorphin II, but not DPDPE, reduced them.
Source: Switching of delta opioid receptor subtypes in central amygdala microcircuits is associated with anxiety states in pain
Journal of Biological Chemistry, 2021
DOI 10.1016/j.jbc.2021.100277 · PubMed 33428940 · PMC7948800, Fig. 4, A–E
Licence: CC-BY-4.0
Named in the paper: “PBN” and “CeA”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5-5) agrees, 2026-10-09
“Stimulating PBN ChR2 terminals in the CeA reliably evoked DNQX-blocked EPSCs, and the DPDPE and deltorphin II effects match Fig. 4D–E.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.