clm-tpy0bc81bw

MEA GABAergic neurons functionally connects to ARH (Arcuate hypothalamic nucleus)

Species: Mouse
Result: present
Method: optogenetic circuit mapping
Sign: inhibitory
Evidence: Blue-light stimulation through a fibre in the ARC of ChR2-expressing MePD GABAergic terminals lengthened the LH interpulse interval in a frequency-dependent way: 10 Hz raised it from about 23 to 38 min and 20 Hz from about 23 to 62 min, whereas 2 Hz, 5 Hz and no stimulation had no effect, and light in wild-type mice without ChR2 had no effect. This indicates that activating this GABAergic input to the ARC suppresses the GnRH pulse generator output.
Source: GABA Signaling in the Posterodorsal Medial Amygdala Mediates Stress-induced Suppression of LH Pulsatility in Female Mice
Endocrinology, 2022
DOI 10.1210/endocr/bqac197 · PubMed 36453253 · PMC9757692, Fig. 5A-F; Results, final section
Licence: CC-BY-4.0
Named in the paper: “MePD GABAergic projection terminals in the ARC” and “hypothalamic arcuate nucleus (ARC)”
Made by: an AI model reading the paper (claude-opus-5, extract@0.3.0), 2026-10-09
Checked by: a second AI model (claude-opus-5) agrees, 2026-10-09
“Frequency-dependent lengthening of LH interpulse interval by optogenetic stimulation of ChR2-expressing MePD GABAergic terminals in ARC, with ChR2-negative controls, supports a functional inhibitory GABAergic input.”
Status: proposed
Drafted and checked by AI models; it stays proposed until people have audited a sample of such claims.