CL:0000101 functionally connects to CL:0000540

Electrical stimulation of the L4 dorsal root with suction and monopolar electrodes evoked monosynaptic EPSCs in lamina II dorsal horn neurons; latency differences gave conduction velocities of ~19.5 m/s for the light-responsive (Aβ) input, and separate groups at ~6.2 m/s (n = 11) and ~0.54 m/s (n = 13) corresponding to Aδ and C fibers in light-unresponsive neurons.

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After peripheral nerve injury, light stimulation of the dorsal root produced large polysynaptic EPSCs in 9 of 10 recorded lamina I dorsal horn neurons, with significantly larger light-evoked EPSC amplitudes than in naive slices, and drove action potential firing in five neurons at resting potential.

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In spinal cord slices with attached L4 dorsal root from ChR2 transgenic rats, blue light applied to the dorsal root evoked monosynaptic excitatory postsynaptic currents in lamina II dorsal horn neurons; the afferents driving these responses conducted at about 19.5 m/s (SEM 1.7, n = 17 fibers), within the Aβ range, and light pre-stimulation blocked the electrically evoked Aβ response, confirming that light drives these fibers.

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In spinal slices from naive (uninjured) transgenic rats, optical stimulation of the dorsal root failed to evoke EPSCs in lamina I neurons, although the same cells responded to electrical stimulation of Aδ and C fibers, indicating no functional Aβ input to lamina I under normal conditions.

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