Mouse

BLA (Basolateral amygdalar nucleus) functionally connects to Isocortex

1 claim from 1 source: 1 found, 0 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-zgt7kxvahtpresentoptogenetic circuit mappingproposed

Halorhodopsin silencing of BLA axon terminals in the vmPFC changed vmPFC calcium activity during observational fear. Shock-suppressed neurons lost their positive freezing correlation, and freezing-positive neurons lost their negative correlation with shock timing. This indicates BLA input shapes the freezing-positive/shock-suppressed subpopulation.

DOI 10.1038/s41467-023-39081-5 · PubMed 37400435 · PMC10318047, Fig. 6i–p; Results, 'Physiological activity in the vmPFC during inhibition of the ACC-vmPFC and BLA-vmPFC pathways'

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