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DR (Dorsal nucleus raphe) functionally connects to BLA glutamatergic principal neurons

2 claims from 1 source: 1 found, 1 tested and absent, 0 ambiguous. Evidence: optogenetic circuit mapping.

The claims behind it

clm-4mv48n38b2presentoptogenetic circuit mappingproposed

Thirty-second 20 Hz optical stimulation of raphe axons produced a slow outward current in nearly all basal amygdala principal neurons, reduced by the 5-HT1A antagonist WAY 100635 but not by GABA receptor blockers, and reduced the principal neurons' firing rate.

DOI 10.1523/jneurosci.2238-16.2016 · PubMed 28087766 · PMC5320609, Fig. 5B–D,G

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

clm-d86p69k57aabsentoptogenetic circuit mappingproposed

Unlike interneurons, basal amygdala principal neurons showed no fast glutamatergic EPSC to single light pulses activating raphe axons, indicating that glutamate-releasing 5-HT terminals do not contact these cells.

DOI 10.1523/jneurosci.2238-16.2016 · PubMed 28087766 · PMC5320609, Results, 'Activation of 5-HT neurons evokes 5-HT-mediated responses in BA PNs'; Fig. 5

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.