Experience-dependent resonance in amygdalo-cortical circuits supports fear memory retrieval following extinction

BLA parvalbumin-expressing interneurons nt-fwck8mp6aj functionally connects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

Optogenetic activation of channelrhodopsin-expressing parvalbumin interneurons in the BLA, with light pulses or sinusoidal waveforms, produced both light-suppressed and light-activated single units in the same nucleus in vivo; the authors interpret the suppression as rapid synaptic inhibition of surrounding BLA neurons, with some cells showing rebound spiking. Spiking of BLA units became entrained to the phase of the 4 Hz and 8 Hz light waveforms.

Fig. 3b–c; Supplementary Fig. 1h–k; Fig. 3d–m

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BLA (Basolateral amygdalar nucleus) MBA:295 functionally connects to PL (Prelimbic area) MBA:972 · Mouse

Rhythmic optogenetic driving of BLA parvalbumin interneurons at 4 Hz or 8 Hz shifted not only the BLA local field potential spectrum but also the mPFC spectrum toward the stimulation frequency, and changed the BLA–mPFC cross-power spectrum, indicating that activity imposed in the BLA propagates to and is amplified in mPFC (in a memory-state dependent way for the cross-power measure).

Results, 'Effects of BLA stimulation on BLA-mPFC oscillatory activity'; Supplementary Fig. 4d,f; Fig. 5d–i

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