Social defeat stress-specific increase in c-Fos expression in the extended amygdala in mice: Involvement of dopamine D1 receptor in the medial prefrontal cortex

AI (Agranular insular area) MBA:95 projects to CNU (Cerebral nuclei) MBA:623 · Mouse

Retrograde Cre-dependent AAV injected into the IPAC of D1-cre mice also labelled D1-expressing neurons in the agranular insular cortex, though far fewer than in the mPFC.

Fig. 4c; Results, 'D1-expressing mPFC pyramidal neurons send direct projections to the IPAC'

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

ILA (Infralimbic area) MBA:44 projects to CNU (Cerebral nuclei) MBA:623 · Mouse

Cre-dependent retrograde AAV (rAAV2retro-DIO-EYFP) injected into the IPAC of D1-cre mice labelled deep-layer pyramidal neurons in the ipsilateral mPFC, with EYFP signal tending to be higher in IL than PL; no labelling occurred in wild-type mice.

Fig. 4c,d; Results, 'D1-expressing mPFC pyramidal neurons send direct projections to the IPAC'

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

PL (Prelimbic area) MBA:972 projects to CNU (Cerebral nuclei) MBA:623 · Mouse

After retrograde Cre-dependent AAV injection into the IPAC of D1-cre mice, EYFP-labelled D1-expressing deep-layer pyramidal neurons were found in PL, though with somewhat lower signal intensity than in IL.

Fig. 4c,d; Results, 'D1-expressing mPFC pyramidal neurons send direct projections to the IPAC'

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.