Pain-Related Increase of Excitatory Transmission and Decrease of Inhibitory Transmission in the Central Nucleus of the Amygdala are Mediated by mGluR1

BLA (basal amygdaloid nucleus) UBERON:0002887 functionally connects to CEA (central amygdaloid nucleus) UBERON:0002883 · Rat

BLA stimulation also evoked longer, more variable-latency IPSCs in CeLC neurons that failed to follow high-frequency stimulation. These IPSCs were blocked by bicuculline and reduced by NBQX, consistent with glutamate-driven disynaptic feedforward inhibition, and they were reduced in arthritic rats.

Fig. 1C-H; Fig. 2B; Fig. 3

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BLA (basal amygdaloid nucleus) UBERON:0002887 functionally connects to CEA (central amygdaloid nucleus) UBERON:0002883 · Rat

In rat slices, electrical stimulation in the BLA evoked short, fixed-latency EPSCs in CeLC neurons that followed 20 Hz stimulation and were abolished by the non-NMDA receptor antagonist NBQX. This indicates a monosynaptic glutamatergic input, and its input-output function was enhanced in arthritic rats.

Fig. 1C-H; Fig. 2A

Made by an AI model reading the paper (claude-opus-5-5, extract@0.3.0); a second AI model (claude-opus-5-5) agrees.