Downregulation of CDK5 signaling in the dorsal striatum alters striatal microcircuits implicating the association of pathologies with circadian behavior in mice

CP (Caudoputamen) MBA:672 projects to TH (Thalamus) MBA:549 · Mouse

Anterograde labelling from the dorsal striatum with AAV-hSyn-mCherry produced labelling in thalamic nuclei of wild-type and control mice; the labelling intensity fell to roughly half of wild-type values in dorsal-striatal CDK5 knockdown mice.

Fig. 7A, B, E

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

CP (Caudoputamen) MBA:672 projects to MOs (Secondary motor area) MBA:993 · Mouse

AAV-hSyn-mCherry injected into the dorsal striatum labelled fibres/cells in the secondary motor cortex in wild-type and control mice; the mCherry signal there was markedly weaker (about 34% of wild-type intensity) after CDK5 knockdown in the dorsal striatum.

Fig. 7A–D

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.

CP (Caudoputamen) MBA:672 projects to BLA (Basolateral amygdalar nucleus) MBA:295 · Mouse

After AAV-hSyn-mCherry injection into the dorsal striatum, labelling was detected in the basolateral amygdaloid nucleus of wild-type and control animals, and this signal was reduced to about 42% of wild-type intensity in mice with striatal CDK5 knockdown.

Fig. 7A, B, F

Made by an AI model reading the paper (claude-opus-5, extract@0.3.0); a second AI model (claude-opus-5) agrees.